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1

A high performance liquid chromatography assay for monitoring proprotein convertase activity

Troii Hall, Kam F. Fok, Min M. Liu, James F. Zobel, Margaret H. Marino, Anne-Marie Malfait, Micky D. Tortorella, Alfredo G. Tomasselli

Journal:

Journal of Chromatography A

Year:

2007

Language:

english

File:

PDF, 736 KB

english, 2007

2

Large scale purification and refolding of HIV-1 protease fromEscherichia coliinclusion bodies

John O. Hui, Alfredo G. Tomasselli, Ilene M. Reardon, June M. Lull, David P. Brunner, Che-Shen C. Tomich, Robert L. Heinrikson

Journal:

The Protein Journal

Year:

1993

Language:

english

File:

PDF, 450 KB

english, 1993

3

Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method

Chou, Kuo-Chen, Tomasselli, Alfredo G., Reardon, Ilene M., Heinrikson, Robert L.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1996

Language:

english

File:

PDF, 1.53 MB

english, 1996

4

Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1

Steven W. Kortum, Timothy E. Benson, Michael J. Bienkowski, Thomas L. Emmons, D. Bryan Prince, Donna J. Paddock, Alfredo G. Tomasselli, Joseph B. Moon, Alice LaBorde, Ruth E. TenBrink

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 219 KB

english, 2007

5

Employing a superior BACE1 cleavage sequence to probe cellular APP processing

Alfredo G. Tomasselli, Isam Qahwash, Thomas L. Emmons, Yifeng Lu, Joseph W. Leone, June M. Lull, Kam F. Fok, Carol A. Bannow, Clark W. Smith, Michael J. Bienkowski, Robert L. Heinrikson, Riqiang Yan

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 370 KB

english, 2003

6

Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

Donald B Carter, Edwige Dunn, Adele M Pauley, Denise D McKinley, Timothy J Fleck, Brenda R Ellerbrook, Nancy C Stratman, Xiangdong Zhou, Carol S Himes, Jeffrey S Nye, Alfredo Tomasselli, Riqiang Yan

Journal:

Molecular Neurodegeneration

Year:

2008

Language:

english

File:

PDF, 830 KB

english, 2008

7

Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: Comparisons with molecular modeling

Narmada Thanki, J.K. Mohana Rao, Stephen I. Foundling, Alexander Wlodawer, W. Jeffrey Howe, Joseph B. Moon, John O. Hui, Alfredo G. Tomasselli, Robert L. Heinrikson, Suvit Thaisrivongs

Journal:

Protein Science

Year:

1992

Language:

english

File:

PDF, 1.11 MB

english, 1992

8

Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease h as substrates of the viral protease

Alfredo G. Tomasselli, Jean L. Sarcich, Linda J. Barrett, Ilene M. Reardon, W. Jeffrey Howe, David B. Evans, Satish K. Sharma, Robert L. Heinrikson

Journal:

Protein Science

Year:

1993

Language:

english

File:

PDF, 3.15 MB

english, 1993

9

Structure analysis reveals the flexibility of the ADAMTS-5 active site

Huey-Sheng Shieh, Alfredo G. Tomasselli, Karl J. Mathis, Mark E. Schnute, Scott S. Woodard, Nicole Caspers, Jennifer M. Williams, James R. Kiefer, Grace Munie, Arthur Wittwer, Anne-Marie Malfait, Mick

Journal:

Protein Science

Year:

2011

Language:

english

File:

PDF, 598 KB

english, 2011

10

Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2

Alfredo G. Tomasselli, W. Jeffrey Howe, John O. Hui, Tomi K. Sawyer, Ilene M. Reardon, Dianne L. DeCamp, Charles S. Craik, Robert L. Heinrikson

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 887 KB

english, 1991

11

Expression and purification of recombinant cynomolgus monkey cholesteryl ester transfer protein from Chinese hamster ovary cells

Jean L. Sarcich, H. David Fischer, Merrill S. Babcock, Joseph W. Leone, Alfredo G. Tomasselli

Journal:

The Protein Journal

Year:

1995

Language:

english

File:

PDF, 962 KB

english, 1995

12

Targeting the HIV-protease in AIDS therapy: a current clinical perspective

Alfredo G. Tomasselli, Robert L. Heinrikson

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

2000

Language:

english

File:

PDF, 1.40 MB

english, 2000

13

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

William Watt, Kenneth A Koeplinger, Ana M Mildner, Robert L Heinrikson, Alfredo G Tomasselli, Keith D Watenpaugh

Journal:

Year:

1999

Language:

english

File:

PDF, 197 KB

english, 1999

14

HIV protease (HIV PR) inhibitor structure-activity-selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH2]Val modified viral and nonviral substrate analogs

TOMI K. SAWYER, DOUGLAS J. STAPLES, LI LIU, ALFREDO G. TOMASSELLI, JOHN O. HUI, KATHY O'CONNELL, HEINRICH SCHOSTAREZ, JACKSON B. HESTER, JOSEPH MOON, W. JEFFREY HOWE, CLARCK W. SMITH, DIANNE L. DECAMP

Journal:

Chemical Biology & Drug Design

Year:

1992

Language:

english

File:

PDF, 595 KB

english, 1992

15

Mitochondrial GTP-AMP Phosphotransferase : 1. Purification and Properties

Alfredo G. TOMASSELLI, R. Heiner SCHIRMER, Lafayette H. NODA

Journal:

Year:

1979

Language:

english

File:

PDF, 669 KB

english, 1979

16

Mitochondrial GTP-AMP Phosphotransferase. : 2. Kinetic and Equilibrium Dialysis Studies

Alfredo G. TOMASSELLI, Lafayette H. NODA

Journal:

Year:

1979

Language:

english

File:

PDF, 709 KB

english, 1979

17

ATP: AMP Phosphotransferase from Baker's Yeast : Purification and Properties

Yasuzo ITO, Alfredo G. TOMASSELLI, Lafayette H. NODA

Journal:

Year:

1980

Language:

english

File:

PDF, 750 KB

english, 1980

18

Baker's Yeast Adenlate Kinase : Evidence of Conformational Change from Intrinsic Fluorescence and Difference Spectra. Determination of the Structure of Enzyme-Bound Metal-Nucleotide by Use of Phosphorothioate Analogues of ATP

Alfredo G. TOMASSELLI, Lafayette H. NODA

Journal:

Year:

1983

Language:

english

File:

PDF, 859 KB

english, 1983

19

ATP-AMP phosphotransferase from Paracoccus denitrificans

Shing-shing YEH, Alfredo G. TOMASSELLI, Lafayette H. NODA

Journal:

Year:

1983

Language:

english

File:

PDF, 770 KB

english, 1983

20

Fluorescence and chemical modification of tryptophan as probes of structure of GTP:AMP phosphotransferase from beef heart mitochondria

Alfredo G. TOMASSELLI, John J. DOUGHERTY Jr, Lafayette H. NODA

Journal:

Year:

1983

Language:

english

File:

PDF, 581 KB

english, 1983

21

The use of nucleotide phosphorothioate diastereomers to define the structure of metal-nucleotide bound to GTP-AMP and ATP-AMP phosphotransferases from beef-heart mitochondria

Alfredo G. TOMASSELLI, Rainer MARQUETANT, Lafayette H. NODA, Roger S. GOODY

Journal:

Year:

1984

Language:

english

File:

PDF, 328 KB

english, 1984

22

Mitochondrial adenylate kinase (AK2) from bovine heart : Homology with the cytosolic isoenzyme in the catalytic region

Rainer FRANK, Marcus TROSIN, Alfredo G. TOMASSELLI, Georg E. SCHULZ, R. Heiner SCHIRMER

Journal:

Year:

1984

Language:

english

File:

PDF, 728 KB

english, 1984

23

Mitochondrial adenylate kinase (AK2) from bovine heart : The complete primary structure

Rainer FRANK, Marcus TROSIN, Alfredo G. TOMASSELLI, Lafayette NODA, R. Luise KRAUTH-SIEGEL, R. Heiner SCHIRMER

Journal:

Year:

1986

Language:

english

File:

PDF, 579 KB

english, 1986

24

The complete amino acid sequence of adenylate kinase from baker's yeast

Alfredo G. TOMASSELLI, Edeltraud MAST, Wolfgang JANES, Emile SCHILTZ

Journal:

Year:

1986

Language:

english

File:

PDF, 761 KB

english, 1986

25

Structural relationships in the adenylate kinase family

Georg E. SCHULZ, Emile SCHILTZ, Alfredo G. TOMASSELLI, Rainer FRANK, Martin BRUNE, Alfred WITTINGHOFER, R. Heiner SCHIRMER

Journal:

Year:

1986

Language:

english

File:

PDF, 531 KB

english, 1986

26

The amino acid sequence of adenylate kinase from Paracoccus denitrificans and its relationship to mitochondrial and microbial adenylate kinases

Peter SPÜRGIN, Alfredo G. TOMASSELLI, Emile SCHILTZ

Journal:

Year:

1989

Language:

english

File:

PDF, 657 KB

english, 1989

27

Recombinant Human Cytomegalovirus Protease with a C-Terminal (His)6Extension: Purification, Autocatalytic Release of the Mature Enzyme, and Biochemical Characterization

Alfredo G. Tomasselli, Donna J. Paddock, Kimberly A. Curry, Robert L. Garlick, Joseph W. Leone, June M. Lull, Veronica T. Mutchler, Carol A. Baker, Gregory S. Cavey, W.Rodney Mathews, John A. Shelly,

Journal:

Protein Expression and Purification

Year:

1998

Language:

english

File:

PDF, 238 KB

english, 1998

28

Production of Chemokines CTAPIII and NAP/2 by Digestion of Recombinant Ubiquitin–CTAPIII with Yeast Ubiquitin C-Terminal Hydrolase and Human Immunodeficiency Virus Protease

Ana M. Mildner, Donna J. Paddock, Lloyd W. LeCureux, Joseph W. Leone, Donald C. Anderson, Alfredo G. Tomasselli, Robert L. Heinrikson

Journal:

Protein Expression and Purification

Year:

1999

Language:

english

File:

PDF, 155 KB

english, 1999

29

[W206R]-Procaspase 3: An Inactivatable Substrate for Caspase 8

Kenneth B. Rank, Ana M. Mildner, Joseph W. Leone, Kenneth A. Koeplinger, K.C. Chou, Alfredo G. Tomasselli, Robert L. Heinrikson, Satish K. Sharma

Journal:

Protein Expression and Purification

Year:

2001

Language:

english

File:

PDF, 799 KB

english, 2001

30

ADAM8 substrate specificity: Influence of pH on pre-processing and proteoglycan degradation

Troii Hall, Lyle E. Pegg, Adele M. Pauley, H. David Fischer, Alfredo G. Tomasselli, Marc D. Zack

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 428 KB

english, 2009

31

An efficient method to express and refold a truncated human procaspase-9: A caspase with activity toward Glu-X bonds

Ramkrishna Sadhukhan, Joseph W. Leone, June Lull, Zhigang Wang, Rolf F. Kletzien, Robert L. Heinrikson, Alfredo G. Tomasselli

Journal:

Protein Expression and Purification

Year:

2006

Language:

english

File:

PDF, 302 KB

english, 2006

32

High yield purification of soluble guanylate cyclase from bovine lung

Karl J. Mathis, Thomas L. Emmons, Daniel F. Curran, Jacqueline E. Day, Alfredo G. Tomasselli

Journal:

Protein Expression and Purification

Year:

2008

Language:

english

File:

PDF, 302 KB

english, 2008

33

Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells

Thomas L. Emmons, Karl J. Mathis, Mary E. Shuck, Beverly A. Reitz, Daniel F. Curran, Mark C. Walker, Joseph W. Leone, Jacqueline E. Day, Michael J. Bienkowski, H. David Fischer, Alfredo G. Tomasselli

Journal:

Protein Expression and Purification

Year:

2009

Language:

english

File:

PDF, 360 KB

english, 2009

34

The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus

David J. Wasilko, S. Edward Lee, Kim J. Stutzman-Engwall, Beverly A. Reitz, Thomas L. Emmons, Karl J. Mathis, Michael J. Bienkowski, Alfredo G. Tomasselli, H. David Fischer

Journal:

Protein Expression and Purification

Year:

2009

Language:

english

File:

PDF, 524 KB

english, 2009

35

Prediction of the tertiary structure of a caspase-9/inhibitor complex

Kuo-Chen Chou, Alfredo G. Tomasselli, Robert L. Heinrikson

Journal:

Year:

2000

Language:

english

File:

PDF, 857 KB

english, 2000

36

Caspase 8: An Efficient Method for Large-Scale Autoactivation of Recombinant Procaspase 8 by Matrix Adsorption and Characterization of the Active Enzyme

Kenneth A. Koeplinger, Ana M. Mildner, Joseph W. Leone, Jean S. Wheeler, Robert L. Heinrikson, Alfredo G. Tomasselli

Journal:

Protein Expression and Purification

Year:

2000

Language:

english

File:

PDF, 189 KB

english, 2000

37

Mitochondrial ATP: AMP Phosphotransferase from Beef Heart: Purification and Properties

Alfredo G. TOMASSELLI, Lafayette H. NODA

Journal:

Year:

1980

Language:

english

File:

PDF, 965 KB

english, 1980

38

Preliminary X-ray studies on the GTP: AMP phosphotransferase from beef heart mitochondria

Emil F. Pai, Georg E. Schulz, Alfredo G. Tomasselli, Lafayette H. Noda

Journal:

Journal of Molecular Biology

Year:

1983

Language:

english

File:

PDF, 274 KB

english, 1983

39

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Thaisrivongs, Suvit, Watenpaugh, Keith D., Howe, W. Jeffrey, Tomich, Paul K., Dolak, Lester A., Chong, Kong-Teck, Tomich, Che-Shen C., Tomasselli, Alfredo G., Turner, Steve R.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 4.16 MB

english, 1995

40

Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere

Thaisrivongs, Suvit, Turner, Steve R., Strohbach, Joseph W., TenBrink, Ruth E., Tarpley, W. Gary, McQuade, Thomas J., Heinrikson, Robert L., Tomasselli, Alfredo G., Hui, John O., Howe, W. Jeffrey

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.97 MB

english, 1993

41

Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase †

Maillard, Michel C., Hom, Roy K., Benson, Timothy E., Moon, Joseph B., Mamo, Shumeye, Bienkowski, Michael, Tomasselli, Alfredo G., Woods, Danielle D., Prince, D. Bryan, Paddock, Donna J., Emmons, Thom

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 162 KB

english, 2007

42

Structure at 2.5-.ANG. resolution of chemically synthesized Human Immunodeficiency Virus Type 1 protease complexed with a hydroxyethylene-based inhibitor

Jaskolski, Mariusz, Tomasselli, Alfredo G., Sawyer, Tomi K., Staples, Douglas G., Heinrikson, Robert L., Schneider, Jens, Kent, Stephen B. H., Wlodawer, Alexander

Journal:

Year:

1991

Language:

english

File:

PDF, 1.51 MB

english, 1991

43

Zinc inhibition of renin and the protease from human immunodeficiency virus type 1

Zhang, Zhong Yin, Reardon, Ilene M., Hui, John O., O'Connell, Kathy L., Poorman, Roger A., Tomasselli, Alfredo G., Heinrikson, Robert L.

Journal:

Year:

1991

Language:

english

File:

PDF, 571 KB

english, 1991

44

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

Thaisrivongs, Suvit, Tomasselli, Alfredo G., Moon, Joseph B., Hui, John, McQuade, Thomas J., Turner, Steve R., Strohbach, Joseph W., Howe, W. Jeffrey, Tarpley, W. Gary, Heinrikson, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 3.60 MB

english, 1991

45

Substrate analog inhibition and active site titration of purified recombinant HIV-1 protease

Tomasselli, Alfredo G., Olsen, Mary K., Hui, John O., Staples, Douglas J., Sawyer, Tomi K., Heinrikson, Robert L., Tomich, Che Shen C.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.31 MB

english, 1990

46

HIV-1 Protease Cleaves Actin During Acute Infection of Human T-Lymphocytes

ADAMS, LONNIE D., TOMASSELLI, ALFREDO G., ROBBINS, PAUL, MOSS, BERNARD, HEINRIKSON, ROBERT L.

Journal:

AIDS Research and Human Retroviruses

Year:

1992

Language:

english

File:

PDF, 1.10 MB

english, 1992

47

Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity

Hall, Troii, Leone, Joseph W., Wiese, Joseph F., Griggs, David W., Pegg, Lyle E., Pauley, Adele M., Tomasselli, Alfredo G., Zack, Marc D.

Journal:

Bioscience Reports

Year:

2009

Language:

english

File:

PDF, 716 KB

english, 2009

48

An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Per Ashorn, Thomas J. McQuade, Suvit Thaisrivongs, Alfredo G. Tomasselli, W. Gary Tarpley and Bernard Moss

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 1.22 MB

english, 1990

49

[Advances in Antiviral Drug Design] Volume 2 || Discovery and design of HIV protease inhibitors as drugs for treatment of aids

Tomasselli, Alfredo G.

Year:

1996

Language:

english

File:

PDF, 3.45 MB

english, 1996

50

[Methods in Enzymology] Retroviral proteases Volume 241 || [15] Specificity of retroviral proteases: An analysis of viral and nonviral protein substrates

Tomasselli, Alfredo G.

Year:

1994

Language:

english

File:

PDF, 1.13 MB

english, 1994